Three Ph.D. students from 1st Batch of Dept. of Biotechnology successfully defended their thesis in open presentation


The research findings of Ph.D. students of Central University of South Bihar (CUSB) may be a prominent option for treatment of liver cancer, cervical cancer are related diseases in future. Three students from the first batch of Ph.D. in Biotechnology have shared the important findings while defending their Ph.D. thesis in open presentation.  The three Ph.D. students namely Nadra Sadaf, Ghanshyam Kumar Satyapal  and Santosh Kumar Mishra successfully defended their thesis under the chairmanship of Prof. Ram Kumar (Dean, SEBES), and current and former Head Prof. Drug Vijay Singh and Prof. Rizwanul Haque, committee members, CUSB faculties, Research scholars and M.Sc. students. CUSB Vice Chancellor Prof. Kameshwar Nath Singh has congratulated the PhD students on the successful presentation and expressed the hope that the country and the world would be benefitted from the valuable outcomes for the treatment of various diseases.

Nadra Sadaf defended her Ph.D. in an open presentation in presence of renowned scientist Prof. Balraj Mittal (External examiner), SGPGI, Lucknow. She was working under the supervision of Professor Rizwanul Haque. Her work was on drug discovery against liver cancer through naturally available components. She used curcumin and arsenic trioxide combination for liver cancer treatment. Her experimental data convinces that drug combination has significant effect on cancer cell apoptosis. Her study suggests that treatment of cancer cells with arsenic trioxide and curcumin combination leads to induction of cellular cytotoxicity, inhibition of cell proliferation, reduction of colony formation ability,  inhibition in wound healing and regulates the apoptotic related protein expression that makes this combination a prominent option for liver cancer treatment in future. Both drugs are cheap as well as easily available so their uses are friendly and most likely adopted by the majority of people if used for treatment purposes in future.

Ghanshyam Kumar Satyapal, defended his Ph.D. in an open presentation in the presence of Professor Arvind Kumar, Department of Biotechnology, BHU as an expert. He has completed his PhD under the supervision of Dr. Nitish Kumar. His work was based on Isolation and functional characterization of genes associated with arsenic transformation in bacteria. This study is significantly important in better understanding and developing the effectiveness of in situ bioremediation techniques by using indigenous microbial communities at arsenic contaminated sites.

Santosh Kumar Mishra under the supervision of Dr. Krishna Prakash successfully defended his PhD work entitled  “A Study on Truncated and Wild-Type Interferon Regulatory Factor -1 (IRF-1) in Normal and Transformed Mammalian Cell Line” in presence of renowned  Prof. R. P. Singh (External examiner), Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi. His work was on a human tumor suppressor gene Interferon Regulatory Factor-1 (IRF-1). He successfully cloned and expressed the gene in E.coli as well as developed a method to solubilise the recombinant protein in E.coli cytosol. His study was aimed to understand the cervical cancer molecular mechanism where such truncated IRF-1 expression is reported. His study has boosted the knowledge of cancer molecular biology to understand the mechanism of oncogenesis caused by truncated IRF-1, which is naturally expressed in cervical cancer patient tissue.



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